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(Electrophoresis of human hemoglobin revealed the abnormal hemoglobin in sickle-cell anemia, the first definitive example of a "molecular disease").
Potential applications for such systems include molecular electronics, semi-conducting (and possibly ferromagnetic) metallocene polymers (an example of a molecular wire), and exploring the threshold between heterogeneous and homogeneous catalysis.
AtGRP7 is the first example of a molecular slave oscillator that autoregulates at the posttranscriptional level.
Also, TOR is another example of a molecular player that integrates signals originating under abiotic stress.
The first example of a molecular information ratchet was described by Leigh and co-workers (Scheme 32 ).
A notable example of a molecular marker of the transition from RGP to VGP melanomas is the β3 subunit of the αvβ3 integrin, a vitronectin receptor.
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Despite its importance for evolutionary change, there are few examples of a molecular basis for this phenomenon.
One of the earliest examples of a molecular machine was a "molecular tweezer" based on the photoisomerization-dependent binding of cations in a crown ether-bearing azobenzene, developed by Shinkai et al. (Scheme 17 ).
Deamidation of Bcl-xL, with consequent abolishment of its antiapoptotic function, thus represents a further example of such a molecular device to change functional properties of those proteins in which it occurs.
Quantitative analysis of EBV DNA is an excellent example of how a molecular tumor marker can contribute to different aspects of patient management, including early cancer detection, staging and risk stratification, posttreatment monitoring, and prognostication.
This clearly qualifies T-1 as a molecular terminator automaton, or an example of a functional molecular robot.
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