For example, even a modest reduction of soluble Aβ has been shown to have a dramatic effect on amyloid plaque formation in animal models [8], and reduction of tau protein levels ameliorates the neurotoxic effects of Aβ in mice overexpressing APP [9].
It should also be noted that the presence in the current study of, for example, a modest but non-differential association (across regions) between financial hardship and lifetime suicidal ideation, tends to suggest that sub-regions with pervasive financial hardship (regardless of geographical location) will tend to experience higher rates of suicidality.
Since 1870, no comprehensive biography of Inhaúma has been published, even though he, according to Francisco Eduardo Alves de Almeira, "is, and always will be, important to the navy of Brazil for his example as a modest and dedicated chief".
One of the best examples of Juvenalian satire is Jonathan Swift's A Modest Proposal.
This report provides an example of how investment of a modest proportion of new HIV/AIDS resources in targeted public health leadership training programmes can assist in building human capacity to lead and manage national HIV and other public health programmes.
For example, while a modest increase in pCr suggests progression of severity, for example, from RIFLE stage R to stage I, renal function may remain unchanged.
The church, with an 1883 Stick style rectory and 1904 Arts and Crafts-style parish hall, is an example of the modest English Gothic parish church popular in the region during the mid-19th century.
So, up to a point, this is a modest example of a much wider disruption.
At the Catholic Charities administrative office in downtown Brooklyn, Mr. Siebel said the Guevara's case is a typical example of the modest and temporary nature of help for the working poor from the Neediest Cases Fund.
But the village is also a perfect example of the modest, eclectic (and frugal) charms to be found in its home province of Guairá (pronounced gwa-ee-RAH), a relatively small area of about 1,500 square miles in the south of Paraguay, a landlocked country that is poor and mostly ignored by the outside world — but spirited and fascinating all the same.
