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The binding domain of riboswitches is a typical example of a genomic aptamer, which senses the concentration of metabolites.
A phyletic vector database, in contrast, is an example of a genomic dataset that will continue to grow in both dimensions: with the addition of novel genomes, the number of genes conserved in at least some of the genomes will also grow.
This is the first example of a genomic lesion affecting a direct cytoskeletal regulator that governs the amoeboid transition.
A landmark example of a genomic marker that has been successfully discovered and validated using RCTs is KRAS.
Chromothripsis is an example of a genomic crisis, which is characterized by spontaneous catastrophic chromosome breakage followed by reassembly resulting in significant loss of chromosomal material [ 62].
In addition, the multiple parallel expansions of the EPA genes, known to be important for the ability of C. glabrata to adhere to human cells, represent a clear example of a genomic change that correlates with the pathogenic trait.
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One of the few examples of a genomic application evaluated by an ongoing randomized controlled trial is the use of breast cancer gene expression profiles to direct chemotherapy to women at high risk of recurrence (40).
Recently, a study using a large number of MAP isolates provided an example of such a genomic polymorphism including 2 large regions of duplication, termed vGI-17 (containing 63 ORFs) and vGI-18 (containing 109 ORFs), observed in most MAP-C strains but not MAP-S isolates [ 21].
An example of a problematic genomic region is presented in Figure 1A.
The hybridization of gDNA to a cDNA microarray is an example of a comparative genomic hybridization (CGH).
A fosmid clone, which has ∼40 kb in insert length, is another example of a short genomic sequence.
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