Ethanol metabolism can drastically change the NADH/NAD+ ratio, providing an example of a metabolic factor that controls gene transcription and thus may influence gene silencing or activation, leading to diseased phenotype.
Male sex is one example of such a factor.
NF-κB is a classical example of a transcription factor subject to negative feedback loops.
Therefore, S1P is an example of a lipid factor that stimulates TRPC channels via a G-protein-coupled receptor.
Figure 1 displays an example of a Common Factor model for the genetic influences in this study.
Alcohol intake is an example of a possible factor not included, just as it was excluded from our study.
Smoking cessation provides departments of community medicine with an example of a lifestyle factor that is relevant to all subspecialty areas of medicine.
Hence, Mafb provides a new example of a transcription factor that can direct post-synaptic differentiation, apparently in a cell-type specific manner.
As such it provides an example of a transcription factor that integrates, balances and co-ordinates hormonal, developmental and environmental signals.
