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For example mice that are null for the TRPV4 channel have hypodipsia and associated hyperosmolarity.
For example, mice that lack UCP-1, essential for mitochondrial uncoupling in BAT, become obese when studied under thermoneutral conditions.[26] With a congenital shortage of native BAT, brite cells could therefore be of great therapeutic interest.
For example, mice that carry a NSC-specific deletion of the chromatin remodeling factor Mll1 develop growth retardation and ataxia during the second week of life and die around 4 weeks of age [28].
For example, mice that have had the insulin receptor gene deleted from adipose tissue are lean.
For example, mice that had completely eliminated their tumours under indomethacin administration were not immune to rechallenge.
For example, mice that had a combination of Cep290 and Mkks disease alleles had better sensory functions than those with either mutation alone [ 136].
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For example, even mice that are MHC matched can vary by miHAs that influence aGvHD severity.
For example, Tg mice that express the human prion protein (TgHu) are used in studies characterizing human prion diseases as well as infectivity of cross-species strains.
For example, transgenic mice that were given 10 mg CLR01 a day per 1 kg body weight intraperitoneally for 30 days showed no apparent toxicity or adverse effects (Attar et al., 2014).
As an example, male mice that do not express a functional Toll-like receptor 4 (TLR4) do not develop pain-behaviors after either nerve injury or inflammation, blockade of TLR4 in the spinal cord reduces pain- behaviors in mice, and activation of TLR4 in the spinal cord produce pain-behaviors.
For example, in mice that are tumor-prone due to heterozygous loss of PTEN combined with reduced expression of LKB1, development of tumors (mostly lymphomas) can be delayed by treating the mice from the time of weaning with metformin or phenformin, or by another AMPK activator, A-769662 [ 79].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com