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For example, mice have about the same number of protein coding genes as humans and over 90% of the mouse and human genomes can be partitioned into corresponding regions of conserved synteny, that is, the order of genes has been conserved since the two species diverged from a common ancestor [54].
For example, mice have few submucosal glands, they have much less airway branching, and do not contain respiratory bronchioles.
For example, mice have relatively short (around 2-year) mean longevity, whereas humans live to a mean of 70-80 years. 70-80 years
For example, mice have been used to fate map cell populations, and other small and large in vivo models have been used to study structural maturation and extracellular matrix patterning.
Even the canonical murine models do not fully reflect human infections: for example, mice have a different commensal microbiome, and typical risk factors in humans include compromised immunity, underlying diseases and old age, which are not represented in the murine model.
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Similarly, the vertebrates, for example mouse, have 6 TRPV and 8 TRPM channels.
For example, mice that have had the insulin receptor gene deleted from adipose tissue are lean.
For example, the mice have major deficits in the hippocampus, a brain area vital for learning and memory.
For example, BMP3 mice have twice as much trabecular bone as wild-type littermates [19].
For example, KPC mice have a lower tumour burden and increased survival time when treated from 4 weeks of age with atorvastatin, a cholesterol-lowering competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme-A (HMG CoA) reductase (Liao et al., 2013).
For example, humanized mice have successfully been used to investigate the individual roles of MHC class II molecules (MHCII) in arthritis and were proven to be useful in identifying T-cell epitopes (reviewed in [ 58]).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com