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In addition, the heart rate is controlled by GqPCR-dependent Ca2+ release, for example mediated by the adrenergic receptors.
Whether this relationship is, for example, mediated by improved psychological well-being or neighbourhood qualities is worthy of further examination.
Xist promoter hypomethylation in Dicer-deficient ES cells could be due to a direct effect on recruitment of DNA methyltransferases (Dnmts), for example mediated by the RNAi pathway.
Modification of the ECM can also be capable of reactivating dormant tumor cells, for example, mediated by integrin-FAK signaling [ 32].
In contrast, pathological hypertrophy is, for example, mediated by increase in pressure overload or hypertension with the heart contracting against an increased after load.
While the earlier work on retroactivity focused on nearest neighbor interactions, for example mediated by the product of a reversible reaction, the ShReD-based analysis also considered interactions between distant parts of a network.
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This is not in contradiction with other potential effects of insulin on cancer therapy; for example, those mediated by insulin receptors on tumour cells (Gualberto and Pollak, 2009).
RAF-inhibitor resistance can, for example, be mediated by the activities of the Wnt (Anastas et al., 2014 ), TGFβ (Sun et al., 2014 ), or RTK (Villanueva et al., 2010 ; Xing et al., 2012 ) pathways.
Higher node degree could, for example, be mediated by the relative time windows of the development of different areas, with lower-type areas appearing earlier in development than higher-type cortices and thereby being able to connect more widely and frequently with newly emerging areas.
The current model gives another such example of coexistence mediated by the processes at other ecological levels.
Relationships between perception and purchase intention, for example, were not mediated by attitude for G1 (see Table 3).
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