In contrast to RA, where the target organ system may be defined as the joints, these diseases have multiple manifestations in multiple organ systems; for example, manifestations of psoriatic arthritis may include arthritis, psoriasis, dactylitis, nail involvement, enthesitis, and spondylitis.
For example, these manifestations could be related to cognitive deficits.
Various disease severity and disease activity markers in RA (for example, extraarticular manifestations, erythrocyte sedimentation rate [ESR], seropositivity, higher joint count, and functional status) have also been shown to be associated with increased mortality [ 31- 33].
Nevertheless, PRO measures for some key concepts identified in the model (for example, skin manifestations of the disease, impact of flares and treatment satisfaction) were either not identified from the literature search, or no PRO has been used to measure these concepts in SLE.
In one recent example, phenotypic manifestations in individuals carrying de novo CNVs associated with variable expressivity correlated with parental phenotypes; parents with lower IQ scores were more likely to have children with a diagnosis of ID/DD and parents with higher social responsive scores (SRS) were more likely to have children with a diagnosis of autism [ 48, 49].
Although type-2 diabetes is pathological in our current environment of surfeit, we hypothesize the disease is a manifestation of an ancient survival mechanism, for example, a manifestation of the ability of the human species to conservatively store and efficiently metabolize calories in times of hardship.
The gray lacuna in Figure 5 between approximately 14 and 20 UT and between roughly 110 and 140 km is an example of manifestation of such blanketing.
"May Day, and Occupy, are both examples and manifestations of non-violent civil protest".
It would be possible, however, to rapidly build a well-curated database integrating other metadata such as, for example, disease manifestation and patient information, including patient genome data.
We discussed fundamental properties that can make it resistant to treatment, and highlighted examples of manifestations of these properties in GBM.
Continuing with our example of conditional manifestations in gene expression, the next step would be to design a set of instructional material and assessments or to refine existing materials based on results from observations of student thinking.
