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Their analysis found poor scientific methodology with for example lack of blinding, lack of evidence of power calculations and likely bias in over-reporting of positive results.
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This is particularly the case given the lack of blinding in most studies.
For instance, the observational study design and lack of blinding are potential sources of bias.
Furthermore, lack of blinding might underestimate rather than overestimate effects for example, a teacher might give extra food to a child receiving a placebo.
One-third of studies had important methodological limitations including differential or incomplete HAI ascertainment or lack of blinding of assessors.
There are obvious limitations to conducting an open-label study, including a lack of blinding and clinician and parent bias.
Another limitation was the lack of blinding.
A major flaw was the lack of blinding.
Second, the lack of blinding may weaken the results of the present study.
Limitations of this study included lack of blinding and the small sample size [84].
Limitations for our project include lack of blinding to the EM physician performing the ultrasound.
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CEO of Professional Science Editing for Scientists @ prosciediting.com