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The kinetics of biochemical reactions in live cells and small volumes, such as organelles, for example, is markedly different from equilibrium kinetics as governed by the macroscopic law of mass action 28– 33.
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Would Saudi Arabia's policies toward the United States, for example, be markedly different if Washington entered into a sustained crisis with Israel over the Palestine issue?
19 For example, UCHL1 is markedly expressed in lung cancer cell lines and primary lung tumors, but not in normal lung tissue.
Take the horizontal texture, for example, the at is markedly bigger than the other three directions.
For example, TNF expression is markedly increased in asthmatic airways compared with normal airways (Bradding et al. 1994).
For example, perihematomal TNFα is markedly increased by 2 4 hours in rat ICH [ 110] and Sun et al. found prolonged increases in perihematomal IL-1β [ 111].
Another example is miR-31 which is markedly underexpressed in human nTreg.
For example, we showed previously that EGR1 is markedly upregulated in the PBMCs of SLE patients.
As an additional example, the potent angiogenic factor VEGF is markedly over-expressed in various cell types in the skin of SSc patients [ 55, 56].
For example, the expression of BMPR2 protein is markedly reduced in the lungs of patients with idiopathic PAH with no detectable mutation in BMPR2 (Atkinson et al., 2002), and cells isolated from PAH patients show altered response to BMP signalling (Morrell et al., 2001).
Whilst epithelial cell Na/K-ATPase activity for example may be markedly altered by such factors the myofibroblasts may also be considered responsive elements.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com