TRH secretion, for example, is inhibited by thyroid hormone, which also inhibits the effect of TRH on thyrotrophs.
Death receptor signalling, for example, is inhibited by cFLIP, and activation of procaspase-9 within the apoptosome is restrained by X-IAP until Smac/DIABLO is released from damaged mitochondria.
In a β cell line, for example, GSIS is inhibited following depletion of native mitochondrial DNA and can be restored by repopulation of cybrid cells with foreign mitochondrial DNA [5].
For example, PKC- α is inhibited during ceramide-induced apoptosis (Lee et al, 1996) and expression of a dominant-negative PKC- α induced apoptosis in CHO cells (Whelan and Parker, 1998).
For example, growth of most microbes is inhibited by 1% to 2% (v/v) butanol, though there are examples of adapted strains of Pseudomonas that can tolerate up to 6% (v/v) [ 17].
For example, the production of melatonin is inhibited when the retina detects light and is stimulated in the absence of light.
For example, the BH3 peptidomimetic ABT737 is inhibited by overexpression of MCL-1, consistent with its BAD like binding selectivity to BCL-2/BCL-XL/BCL-W.
For example, when Topo II function is inhibited by the Topo II poison R16 in human cells, a reduction of the DNA damage check point protein Chk1 is observed without greatly effecting Chk1 mRNA levels [52].
In carp, for example, at <14°C, adaptive immunity is inhibited, but the innate immune response remains functional (36).
When replication fork progression is inhibited, for example as a consequence of reduced dNTP supply or due to forks encountering DNA damage, some origins which otherwise would have remained dormant are activated.
For example, binding of β-catenin is inhibited by CSNK1 phosphorylation of human E-cad Ser844 (designated by "" in the CBD of Fig. 2A) (Dupre-Crochet et al., 2007), which we found to be well conserved in metazoans.
