For example, in vitro MSCs were capable of differentiating into cardiomyocytes, as demonstrated when MSCs were co-cultured with neonatal ventricular myocytes [35].
For example, in vitro a high dose of leptin has been found to elicit a great amount of TNF-α and IL-6 secretion from activated human peripheral blood mononuclear cells (PBMCs) [38].
For example, in vitro γ-secretase activity is measured routinely using a recombinant substrate derived from APP [23].
For example, in vitro treatment of PBMCs from SLE patients with estrogen results in polyclonal activation, secretion of antibodies to double-stranded DNA, and defects in apoptosis of immune cells [5], [6].
For example, in vitro evidence suggests that membrane receptor aggregation triggers signaling responses.
For example, in vitro collagen 1, fibronectin, laminin and entactin derived peptides exhibit chemotactic activity for inflammatory cells [ 49, 52].
For example, in vitro exposure to etoposide plus nutlin-3a allows the detection and identification of ATM and TP53 mutations.
For example, in vitro AR is activated in a ligand independent manner by EGF (Culig et al, 1994).
For example, in vitro evidence suggests that melatonin prevents the death of neuroblastoma cells exposed to Aβ [ 16].
For example, in vitro inhibition of docetaxel clearance via CYP3A4 is seen with concomitant administration of vinorelbine, vinblastine, and doxorubicin.
included fewer AE terms used broad terms such as 'cause' and 'response' and applied specific study design filters, for example, in vitro studies.
