For example, in T2D, the established susceptibility gene PPARG encodes a protein which is a target for the thiazolidinedione drugs.
For example, two variants in the established type 2 diabetes (T2D) susceptibility gene TCF7L2 have been shown to influence the response to treatment with sulfonylurea drugs.
For example, in the longest established experimental proteomics resource, SWISS-2DPAGE [ 7], the emphasis is on annotated gels, and there is much less information collected on how the annotations were arrived at.
That would be an example of how in challenging the established world order, we could transform reality for the better.
For example, in an established murine fibrosarcoma model, the maintenance of M2-phenotype was associated with defective NF-κB activation.
Minor comments: "[defense island formation] occurs fortuitously due to non-adaptive clustering of horizontally transferred genes" perhaps horizontally transferred genes may also cluster adaptively, but not because of their molecular functions but because, for example of the advantage in avoiding the established genome neighborhoods?
For example, in the 1990s, Maine established a program that allowed doctors in four specialties--anesthesiology, emergency medicine, obstetrics and gynecology, and radiology--to participate in a program allowing use of guidelines as exculpatory evidence in lawsuits.
For example, in 2007, UAE established the National Emergency and Crises Management Authority (NCEMA) with the objective of dealing with disasters and coordinating with different concerned organizations (http://www.ncema.gov.ae/).
(4) The outcome of HTA is used to inform decisions concerning the allocation of budgetary resources in the field of health, for example, in relation to establishing the pricing or reimbursement levels of health technologies.
For example, in order to establish the mini-compost pile in the machine's mixing chamber, the instructions tell you to throw in a couple of cups of native soil from your yard, containing the appropriate micro-zoology to decompose the waste.
