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For example, in animal models opioid agonists reduce isolation distress whereas opioid antagonists increase isolation distress.
Among these, several lines of evidence support a dose-dependent effect of these drugs on angiogenesis; for example, in animal models, inflammation-induced angiogenesis is enhanced with low-dose statin therapy but inhibited at high statin concentrations, and high-dose statin concentration is associated with decreased tumor vascularization in a lung cancer model [2].
A particularly important example in animal cells is cholesterol, which helps strengthen the bilayer and decrease its permeability.
As one example, in animal models, after an initial increase in glucose metabolism, there is a subsequent reduced metabolic state which may persist for up to four weeks after injury.
This result is of great importance to researchers interested in the effects of prenatal manipulations, for example, in animal models of human disorders.
This suggests that in vivo μCT may be used to evaluate change in mineralized bone density and trabecular architecture over time, which may be caused by disease or therapy, for example, in animal models.
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For example, in-vivo animal models may experience variable collateral blood flow, which can potentially interfere with the infarct size, and is difficult to control for.
For example, in animals, delivering miRNAs into cells can cause their transcriptomes to resemble the transcriptome of the tissue where the miRNA is preferentially expressed [33].
For example, in animals that are sensitized to ova albumin and infected with M. pneumoniae, airway remodeling can be observed suggesting that M. pneumoniae mediated inflammatory responses are capable of causing long-term lung damage [10].
This type of analysis is particularly relevant to EST studies as the probability of obtaining a full complement of taxa for a particular ortholog is reduced as the number of taxa in the analysis increases (see [53] for an example in animals).
For example, in animals and yeast, SUMO modifications affect cell cycle progression, DNA replication and repair, protein activity and stability, chromatin structural maintenance, subcellular localization and transcriptional regulation, as well as oxidative stress responses [ 4, 5, 10, 14– 17].
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CEO of Professional Science Editing for Scientists @ prosciediting.com