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Although mRNA translation plays a vital role in every cell in the organism, surprisingly, loss-of-function mutations in translation factors and their regulators often result in defects restricted predominantly to the nervous system, for example imbalance in excitatory and inhibitory synapses (Geschwind and Levitt, 2007; Gkogkas et al., 2013).
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There are several theoretical approaches to these problems, for example the imbalance effort - reward (ERI) model, which has been poorly tested in the ICUs.
For example, an imbalance in the intracellular glucose metabolism leads to increased levels of its oxidative breakdown products dicarbonyls glyoxal (GO), methylglyoxal (MGO), 3-deoxyglucosone (3-DG) and glucosone.
Example for imbalance: distribution of age categories was statistically not comparable (p value less than 0.05).
For example, occupational imbalance, defined as interference among occupations, was negatively associated with subjective wellbeing [ 49] and life satisfaction [ 45].
In this example, the imbalance was detected even when only one allele was used in the alignment.
This finding could suggest that TSH might be associated with systemic processes interacting with carcinogenesis, for example, hormonal imbalance or inflammation, rather than with the local neoplastic transformation.
For example, the imbalance of power existing between different groups of stakeholders [ 27, 28] means that some topics can be neglected during this process because people who defend them do not receive enough consideration within the group [ 29– 31].
Potential markers include, for example, allelic imbalances, chromosomal instability, expression of oncogenes, loss of tumour suppressor genes, markers of proliferation, angiogenesis, inflammation and cell adhesion as well as genes involved in the response to chemo- and radiotherapy.
The two approaches are illustrated by examples involving imbalance excitation and kinematic excitation of the baseplate.
For example, small imbalances in contrast have a much greater effect in determining initial dominance than in influencing subsequent switching in sustained rivalry [23].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com