One of the first examples for the interplay of different histone modifications was the observation that phosphorylation of S10 in H3 facilitated the acetylation of H3-K9 and K14, whereas methylation of H3-K9 inhibithe the phosphorylation of S10 (Rea et al., 2000), although later evidence indicated a possible coexistance of phosphorylated S10 and methylated K9 (Mateescu et al., 2004).
For example, as an example of the interplay between problem formulation and biological considerations, discussions between risk assessors and research scientists can improve the efficiency of risk assessments by focusing resources on tiered and/or targeted approaches that are more efficient and reduce animal use (Meek, 2008; Meek & Klaunig, 2010), as envisioned by NRC (2007a).
Orogenic plateaus represent a prime example of the interplay between surface processes, climate, and tectonics.
Asia provides several examples of the interplay.
In the future, the model could be complemented by more detailed models for the hierarchical structure of adhesion contacts, for example the interplay between integrins, talin, vinculin and the actin cytoskeleton.
New insights into the pathophysiology (for example the interplay between intraalveolar coagulation/fibrinolysis and inflammation and the genetic polymorphism for the angiotensin-converting enzyme) offer new therapeutic options.
For example, the interplay between quantum physics and relativity can be probed through quantum communications between moving observers and within schemes in a curved spacetime background [2].
For example, the interplay between particle strengthening and grain size influence on macroscopic flow stress behavior is shown, as well as effects due to dynamic recrystallization.
This separation of concerns has led to system engineering practices that are not designed to reflect, detect, or manage the interdependencies of such aspects, for example, the interplay between security and safety in modern car electronics, or between security, privacy, and reliability in connected medical devices.
However, to understand other aspects of the tumour suppressor function of p53, for example the interplay of responses to DNA damage and hypoxia, the interaction of multiple PTMs may be important and could be tackled by modelling using methods similar to those employed here.
