A particular convincing example for the sequential action of two cytokines was observed after activation of NK cells by ligands of TLR3, TLR4, TLR7 or TLR9, which was strictly dependent on IFN-α/β signaling as well as IL-15.
b Example of sequential data.
Figure 5 Working example of sequential operation of three readers.
A recent example of sequential mediation is reported in a study on mediators of multisystemic therapy outcomes for adolescents with externalizing problems (Deković et al. 2011).
The performance and scalability of atmospheric transport models on high performance computing environments is often far from optimal for multiple reasons including, for example, sequential input and output, synchronous communications, work unbalance, memory access latency or lack of task overlapping.
The optimal schedule of treatment (for example, simultaneous, sequential or syncopated TKI regimens) for treatment of patients with concomitant PV/CML is still unclear, but can potentially be guided by molecular monitoring and biologic correlative analyses.
For example, sequential quadratic programming methods, trust region approaches [1], penalty methods and interior point methods [2].
For example, sequential rejuvenations, incapable of guaranteeing that the overall system is reset to a completely healthy state, allow a subtle time-window of attack not present in truly periodic parallel rejuvenations.
For example, sequential administration of K-111 at doses of 1, 3, and 10 mg/kg per day (4 weeks for each dose) to obese rhesus monkeys reduced TG by 30, 50, and 53%, respectively (Bodkin et al. 2003a).
However, the use of other drugs with lenalidomide requires careful consideration of dosing and scheduling; for example, sequential treatment with ofatumumab and lenalidomide may be associated with a higher rate of TFR (57%) than shown with concomitant therapy [ 46].
