For example, for oestrogen receptor β it has been reported that alternative 5' UTR influences splicing and may alter protein function [ 20].
For example, a receptor for stress hormones can cause a biological change in the fetus, which makes it more vulnerable to stress after birth -- this links to hyperactive disorders.
The MEF2 motif, is for example a receptor for the mammalian MEF2A, MEF2B, MEFC and MEFD transcription factors [ 48].
Similarly, in different human receptor proteins the importance of their site-specific phosphorylations could be demonstrated, for example in receptor tyrosine kinases of the ErbB family [ 51].
For example, for the lutropin receptor (LHCGR) it has been suggested that the beta-gamma subunit of Gi activates phospholipase C [86].
These results are reminiscent of reports of the schistosome transcriptome where, for example, receptors for mammalian hormones, including insulin, fibroblast growth factor and cytokines, have been hypothesized to bind host molecules (reviewed in [ 25]).
This cornucopia of targets includes other approaches that can modulate cytokines (for example, adenosine A3 receptors), proteases (for example, collagenases), ion channels (for example, P2X7 receptor), and innate immune responses (for example, IFNs and Toll-like receptors).
For example, for growth factor receptors, the activation under normal conditions promotes cellular survival, whereas over-expression promotes tumor cell growth [51].
For example, olfactory receptor proteins were found important for vertebrate diversity [ 42] as were protein families associated with cell communication.
For example, receptor imaging and tumor therapy require high specific activity or low concentration of the peptide, due to the limited number and affinity of transmembrane tumor receptors.
Structural interventions to improve metabolic stability often deteriorate other important biological features of radiopeptides, as for example receptor affinity or pharmacokinetics [9].
