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Accordingly, our findings provide a clear-cut example for functional differentiation among paralogs; the teleost PP1 could have retained the putative ancestral function, whereas teleost PP2 acquired a novel functional role via a neofunctionalization event.
Figure 2 Example for functional discrepancy in the image processing domain.
For example, for functional PSII subunits, fPSII = fPSIIH+fPSIIP, where fPSIIH and fPSIIP contain host D1 and phage D1, respectively.
Accepting the polyphyletic origin for sFRPs, they constitute a similar example for functional convergence based on convergence of domain architecture.
We argue that such gene graphs may be considered as single units for downstream analysis of metagenomes, for example for functional predictions by similarity search.
An example for functional alternative splicing in Arabidopsis is a TAGCAG acceptor affecting the RNA-binding domain of the U11 35K protein that results in different binding affinity for SR proteins and the U11 snRNA in vitro [ 42].
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If so, HSFY could be one of the examples for functional selection.
We enlarge positive example set with different times for different groups and set k = 10, which is shown in Table 7. Particularly, we did not make synthetic positive examples for functional classes with more than 300 annotated genes.
For example, for the functional category "translation", many more genes were classified as ubiquitous compared to SAE-enriched and those that were SAE-enriched were expressed at higher levels than expected based on all genes.
Other examples of ordinal outcome scales can be found in cardiology (for example, NYHA Functional Classification for heart failure), vascular surgery (for example, Rutherford Classification for peripheral artery disease) and pain management (for example, Visual Analogue Scale).
Studies on leukaemias have provided paradigmatic examples for the functional implications of genetic and epigenetic alterations in cancer development [ 25, 26].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com