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Far too often, however, repeat sampling is neither the standard of care nor straightforward (for example, for bone or brain metastases), thereby significantly complicating the ability to assay recent tumor samples to identify new therapeutic targets.
Patients with hormone sensitive tumours who were still receiving hormone therapy but who had developed hormone resistant disease were eligible to participate, as were patients receiving palliative radiotherapy that was not expected to prolong survival (for example, for bone metastases).
The amount of bone supplementation required and its intended purpose dictates the source of the tissue: for example, for bone inductive purposes, a supplementation of fresh autologous cancellous bone containing cellular, mineral and humeral components is required, and is usually taken from a non-involved body site.
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The detection strategy may also be used for other sources of cells, for example, from bone marrow, sputum, urine, breast nipple aspirates, lymph nodes or colonic washings.
The gradient of risk, for example, of bone mineral density measured in the hip to predict hip fracture is 2.6 (Marshall et al, 1996).
It is common among ballet dancers, for example, for the bones of the foot to thicken from the extra weight they bear, Ms. Liederbach says.
The existence of multiple variants implies a more complex function of RANK in those cells (for example, MaSCs, osteoclasts), tissues (for example, mammary, bone) and tumors (for example, breast tumors) whose survival, development and differentiation depends on expression of the RANK receptor.
In the case of cartilage MPCs, most approaches use markers already successfully described for other tissues (for example, bone marrow).
For example, bone age is delayed in children with growth hormone deficiency and accelerated in children with growth hormone-producing tumours.
For example, bone density is higher in men than in women and is higher in African Americans than in Europeans or Asians.
For example, bone attenuation is difficult to implement into Dixon-based AM as bones are not readily identifiable on standard MR images.
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