The reason why such thing happens is that the optimal solution ignoring the lower level objective function for the example is just feasible to it.
For example, it is feasible to consider that gene deletions may have different effects from point mutations, and that the consequence of a point mutation will vary according to its location in the protein or its effect on gene expression.
When determining how the cutoff value c is selected, the relative importance of sensitivity, specificity, PPV, and NPV needs to be considered with respect to some form of cost benefit measure: For example, is it feasible to vaccinate a large number of people unnecessarily if it means that a large proportion of cases are prevented?
In the case of cyanotoxin degraders, for example, it would be feasible to assign the biodegradation pathway of cyanotoxins to specific bacteria (i.e., single-cells) from any toxic cyanobacterial water bloom, regardless of their cultivability.
For example, it is not feasible to examine pain differences between the L3/L4 and L5/L6 disks.
For example, it was not feasible to analyse biological samples of all CKDu cases for all heavy metals.
For example, it may not be feasible to conduct a pragmatic trial of outreach for patients past due for cancer screening using traditional informed consent.
For example, it may not be feasible to conduct a large, long-term study of the comparative effectiveness of CSII versus MDI on cardiovascular outcomes, and future studies will have to consider the appropriateness of using surrogate or intermediate outcomes as alternatives.
To test this hypothesis, it should be feasible to collect examples of the three types of outcome data that were identified by Farber et al. [ 4] as appropriate for an evaluation of the navigator role.
There are useful examples showing that it is feasible to catalyse the formation of Elders' Clubs or older people's associations which become self-sustaining, promote social participation, and improve health and well-being of elders and their families.
