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Although all of these phenotypic hallmarks are shared between RXRs and Notch mutant mice, they also exhibit certain differences; for example disease progression of the RXRs mutant mice appears to be milder, it affects primarily ear skin and later to a lesser extent dorsal skin.
For example, disease progression in and clinical outcomes of breast cancer were predicted in a pioneering study based on examining changes in the connectivity of 'hub' proteins in tumor cells.
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For example, monitoring disease progression or the timing of developmental defects is important for the processes of drug discovery and therapy trials.
Examples of disease progression for individual mice are shown in Figure 3B.
For example, disease initiation or progression may be reliant on Wnt activation with the concomitant inhibition of Notch signalling mediated by crosstalk.
This framework enabled the inference of the temporal order of genetic driver events in CLL, with the identification of earlier (for example, MYD88 mutation) and later events (for example, TP53 mutation) in disease progression.
For example, sgp130Fc significantly prevented disease progression in inflammation-associated mouse cancer models.
This enables the detection of small and focal changes in anatomy, which is important for example for tracking of disease progression.
For example, a delay in disease progression may not always be viewed as "effective" from the payer's perspective despite analyses showing that it often reduces long-term costs particularly for age-related diseases.
For example, modifiers of the disease progression that takes place after many of the vulnerable striatal neurons have already died may well reveal different pathways and targets for intervention.
The RCI is calculated from a control group by considering the test-retest reliability, SD, and a systematic bias of the score change between the first and second test occasion (for example, training effect or disease progression) [ 24].
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