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For example, diagnostic tests have been developed to stratify patients based on gene expression and are currently being prospectively evaluated.
For example, diagnostic tests that measure the abundance of a given protein in serum may be derived from a small subset of biologically relevant genes.
Publicly funded services are divided into 22 different categories, for example, diagnostic tests including medical laboratory diagnostic, services aimed at health protection, prevention of diseases and injuries, early detection of diseases, including compulsory vaccinations, primary health care, outpatient specialist services, and inpatient care.
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For example, diagnostic testing to identify high-risk smokers can include expensive airway pulmonary function tests or bronchoscopy.
The report must provide a full and clear interpretation of results, depending both on the clinical context and the reason for referral (for example, diagnostic test, carrier test, prenatal test).
Every state's package will cover visits to primary care doctors and specialists, for example, and diagnostic tests like X-rays and blood work.
Dedicated research centres such as the NIHR-funded Biomedical Research Unit in Lewy Body Dementia at Newcastle University have led the field by, for example, developing diagnostic tests such as the dopamine transporter SPECT scan, which can distinguish DLB from Alzheimer's with >85% accuracy and which is now widely clinically available.
Clinical questions and the corresponding requirements for biospecimen detection determine the ability of MS to find and routinely measure high-quality biomarkers that have sufficient sensitivity and specificity to be clinically useful in screening large populations - for example, for diagnostic tests or early disease detection.
For example, there are diagnostic tests based on genetics (Oncotype DX® and MammaPrint®) that place breast cancer women into different risks categories for which there are specific treatments.
Developments need to be adapted to the population, including for example innovations in diagnostic tests, outreach support through tele-medicine and improved access to medicaments, with the value determined by cost-effectiveness studies.
In some cases, PSI has introduced new products, for example, malaria rapid diagnostic tests, but most often the approach focuses on changing provider behaviors and practices to improve the quality of existing services.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com