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For example, compounds with similar chemical fingerprint profiles tend to have similar biological activities (Petrone et al., 2012).
For example, compounds with a high octanol/water partition (log P) will be very soluble in organic materials and may exhibit considerable loss in the ECMO circuit [ 6].
This results from physiochemical properties: for example, compounds with fewer rings tend to partition into air and water, and usually degrade much faster than compounds with more rings (SI Table S2).
This is by no means a highly quantitative relationship; for example, compounds with larger envelope violations can have smaller worst-fold affinity losses (AF-78 vs AF-69), particularly against a relatively small panel of mutants.
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This raises the possibility that the genuine phosphate acceptor of TM0415 is a compound other than myo-inositol: for example, compounds related with the myo-inositol metabolic pathway that is composed of enzymes encoded by the TM0411 TM0416 operon in T. maritima, such as 2-keto-myo-inositol, diketo-inositol, 5-keto-l-gluconate, and d-tagaturonate (Supplementary Fig. 1b 23.
For example, compound 9 with an α,β-unsaturated moiety but no TJ-opening ability does not induce a Ca2+ influx (Suppl. Fig. S3).
For example, compound 4k with chorine at the 2-position of the benzene ring possessed high inhibitory activity against G. azeae, whereas compound 4l with chorine at the 4-position of the benzene ring displayed moderate activity.
For example, compound 10 with a p- tert-butyl substituent has Ki values of 236 nM to cIAP1 and >18 μM to XIAP, a selectivity of >700 times for cIAP1 over XIAP.
In the above-mentioned example, compounds might be called biogenic with respect to their source and abiogenic with respect to the process they were generated along.
Analyses of foods undergoing Maillard reactions have shown that the process releases hundreds of compounds, some of which have been harnessed by the flavour industry to create processed foods that taste better — compounds that contain the amino acid cysteine provide a meaty smell, for example, and compounds with methionine enhance the flavour of potatoes.
50, 51 Cardiac glycosides (e.g., digoxin and related compounds) are an example of compounds with a large difference in affinity between species, in the order of 100-fold lower affinity in rodents compared with humans.
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