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For example, compounds that contain water exhibit a constant temperature region as the water is stripped from the compound even though heat is continuously added.
For example, compounds that are predicted to be unstable at pH 7, could have significantly greater stability at, for example, pH 5.
Results uploaded to the CASMI contest website as well as our post hoc tool comparison clearly show that in silico algorithms alone are still far away from practical use for identification of true unknowns, for example, compounds that are not currently represented in chemical or biochemical databases.
For example, compounds that would be effective agents for treating stage II HAT infections would need to be brain penetrant.
For example, compounds that target SMAC-binding sites on BIR domains activate the intrinsic E3 ligase activity of IAPs, causing their self-ubiquitinylation and subsequent proteasome-dependent degradation (Zhang et al, 2004).
For example, compounds that preferentially bind to amyloid fibrils (11-C Pittsburgh compound B, F-florbetapir, F-flutemetamol, and F-florbetaben) are available, and studies to date indicate they sensitively report cerebral amyloidosis on PET scans.
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For example, bitter compounds that enter the large intestine under normal conditions are most frequently bile acids and their bacterial metabolites.
For example, antifungal compounds that are released into soil by one plant can influence the endophyte communities of surrounding plants, constituting a plant-imposed habitat filter that is mediated by neighbors of the host.
This review will describe the design of activity-based proteomics probes, provide examples of compounds that have been used to profile activity in the area of carbohydrate-processing enzymes, and give some future perspectives.
Although animal models are commonly used in pre-clinical research, there are many examples of compounds that are safe in animal models or efficacious in an animal disease model, but toxic to a human or ineffective for treating a human disease.
Examples of compounds that have attracted researchers to topical skin applications are polyphenols, triterpenes and stillbenoids.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com