For example, compartment-specific biosensors have also been used to estimate the diffusion rates of cAMP from its site of production at the plasma membrane into the nucleus [ 12].
For example, compartments not of primary interest may be brought together as a single artificial composite compartment (Mayhew et al. 2002).
Finally, we can easily extend the format to describe new classes of problems, for example with compartment modelling and system modifications like gene deletions.
Whereas Golgi and ER were easily detectable by appearance in control photoreceptors (Fig. 4E, inset for second example), neither compartment was morphologically identifiable in Sec13-suppressed photoreceptors (Fig. 4F, inset for second example).
For example, three compartments, anterior, posterior and medial, exist in the thigh, and four compartments, anterior, deep posterior, posterior and lateral, are present in the calf.
As a second example, liver compartments displayed strong "immune response" GO-terms that may be a part of a host counterattack against the invading tumor.
That these stores represent small vesicular structures adds to the versatility of the Ca2+ signaling apparatus by providing for a mechanism of quantal Ca2+ release that may be utilized to "filter" Ca2+ signals at junctional complexes between endolysosome stores and, for example, S/ER compartments.
Other problems encountered involved errors in human curation of the network model, such as enzymes curated as existing in the wrong compartment (example: HMGCoA Reductase in peroxisome but not cytosol).
The proportion of cell volume that is cytosol varies: for example while this compartment forms the bulk of cell structure in bacteria, in plant cells the main compartment is the large central vacuole.
Although in the high concentration range an underprediction can be observed suggesting, for example a three-compartment model, a two-compartment model resulted in a better fit to the data.
Also check to see if the car looks too clean compared to other vehicles -- for example, the engine compartment is spotless when it shouldn't be for a car of its price and vintage.
