One example of a cell based treatment that has improved over the past 20 years is a technique called autologous chondrocyte implantation (ACI).
Although FastSNP did accurately predict the potential effect for the 4 SNPs serving as intronic enhancers along with the intronic SNPs in ROBO1 and LPHN2 as not having any effects, these predicted changes are only suggestive at this stage and will need further validation using; for example, in vitro cell based functional assay systems.
Figure 1 Example of division of a cell based on measurements.
Together this study is the first example of using population and single cell based transcriptome analyses to unveil the molecular interplay between different NSC/NPCs and their microenvironment in the context of the aging brain.
Orthobiologics is a relatively newer science that involves application of naturally found materials from biological sources (for example, cell-based therapies), and offers exciting new possibilities to promote and accelerate bone and soft tissue healing.
For example, cell-based biosensing for drug development, biomedical implants, and tissue engineering require that the surface adhesion of living cells is well controlled.
For example, cell-based treatments with the aim of recovering pancreatic β cell function, including the pancreas transplantation, islet transplantation, and stem cell transplantation, focusing on replacing damaged β cell populations, should be the ideal potential therapeutic pathways [2].
For example, cell-based products that involve the destruction of a human embryo in their formation are initially licensed by the HFEA.
For example, cell-based bioreactor systems including plant suspension cells and algae are ideal for lower-volume products, whereas field-grown commodity crops can produce metric tons of recombinant protein at highly competitive costs.
For example, cell-based assays analogous to key neurodevelopmental processes such as neural precursor commitment, neuronal and glial cell migration, proliferation, differentiation, synaptogenesis, neurite outgrowth, functional measurements of electrical activity, ratio between neuronal and glial cells provide a reliable mechanistic insight into a potential DNT's effects (Bal-Price et al. 2012 ).
For example, in 2010, Venter et al. created a Mycoplasma mycoides cell based on the essential genes of M. mycoides[ 5].
