In the case of UVR8 signaling, an exaggerated response would result in impaired growth and dwarfism (as illustrated, for example, by experimental UVR8 overexpression) [ 5].
Whether a positive feedback loop found by the procedure is important in a biological or experimental context, is not addressed in this paper, but must be established in other ways, for example by experimental verification.
Major advances are being made through a combination of natural, long-term studies and experimental approaches, for example by experimentally manipulating the environment and measuring phenotypic and/or genetic/genomic change.
In our collaboration on diabetes, for example, data generated by experimental colleagues contribute to modeling and building a concerted mathematical effort at understanding the disease.
A prototype version of the simulation environment has been developed using C++, and the feasibility of the proposed approach has been illustrated using practical examples backed up by experimental data.
This could be accomplished, for example, by either collecting independent experimental binding data or training the method on clusters of similar binding sites, which presumably bind the same or chemically similar ligands.
For example, by analogy, there is experimental evidence that Chlorpyrifos exerts neurodevelopmental impacts at lower concentrations than would be needed to impact on cholinesterase function [ 82] and similar findings have been made in relation to other orgranophosphates [ 83- 85].
This framework was illustrated by multiple numerical examples concerning irreversible adsorption, and by experimental data corresponding to oxygen adsorption on polycrystalline platinum.
If, for example, the hormone auxin is prevented, by experimental means, from influencing the plant, the plant lives longer than normal and undergoes an atypical prolonged pattern of senescent change.
It is therefore possible for seemingly contradictory terms to be attached to the same protein, even when supported by experimental evidence (for example, when a protein has been identified in independent published studies of two different organelles).
The modENCODE implementation of this approach has enabled the project to provide complex data search and filtering capabilities via integration with the modMine (http://intermine.modencode.org/) tool allowing for data retrieval and display in GBrowse (15) by for example, particular experimental conditions or reagents.
