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However, evolutionary pressures change, for example as additional genes are acquired, allowing established protein folds to be put to other uses.
For example, as additional data emerges for the role of glycosylated hemoglobin (A1c) in diagnosing diabetes in African populations, this testing strategy can be utilized to provide point-of-care confirmation in one encounter with or without prior screening.
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The following examples as well as additional example models can be loaded and demonstrate the concrete syntax of ML-Rules.
The landscape model includes only information about the shape of the landmass to keep our example as simple as possible, but additional variables could be added (see Discussion).
However, these challenges are mitigated by providing example code as additional files.
The group advises parents to put something they will need by their child's car seat — a purse, wallet or phone, for example — as an additional reminder to check the back.
The better approach, however, is to use the stability profile as soft constraints; for example, as an additional pseudo-free energy change term in the MFE structure prediction algorithm [ 64].
We re-examine those here, and present additional examples as well.
The dataset with simulation results for our example is attached as Additional file 1.
An output text file is also created, containing all the results of the computational analysis (an example is presented as Additional file 4), such as the peak count for each sample, the identification of "active" vs. "inactive" cells (based on the presence of at least 3 peaks) and the autocorrelation analysis of peak-to-peak intervals (waiting times).
For example, as shown in Additional file 1: Figure S3 B, FLD1_32_F06.b1_A029 has a complex concatenated adapter immediately before the 3TNS terminus: CCTCGTGCC (Adapter1 in non-sense direction) is connected to GAATTC (EcoRI site); GAATTC is concatenated to GGCACGAGG (Adapter1 in sense direction); GGCACGAGG is concatenated with CCTCGTCC again, which is part of the normal 3TNS terminus.
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