One example is AGOS_ACL044W, annotated in KEGG with the EC number 1.2.1.3 and in the current annotation with 1.2.1.5.
Iron as a metallic element, for example, was not annotated in CHEMDNER and SCAI, but is considered a drug (i.e., a vitamin) in the DDI corpus.
For example, NpR1276 is annotated in GenBank as an acetolactate synthase, which is a thiamine pyrophosphate (TPP -requiring enzyme.
A different example is AGOS_ADR323C, annotated in KEGG as an Isomerase (5.4.2.1), but as a Hydrolase (3.1.3.37) in the present annotation.
Authors' response: We acknowledge that these examples are already annotated in many genomes with the associated function.
For example, the relative abundance of COG categories annotated in this example shows no visible difference to that in original literature (Supplementary Figure 17b) [ 39]. a Detailed parameters are explained at WebMGA website.
For example, most of proteins are annotated in another database (i.e. Pfam) as the target function.
For example, there are 174 genes annotated in the X. maculatus genome that were not transferred to X. hellerii.
A relatively small number of sequences are carefully aligned and annotated in databases, for example, Cole et al. (2009); Punta et al. (2012); Sigrist et al. (2010).
For example, BGIBMGA003910-PA, which is poorly annotated in the silkworm database, has orthologus in other insects (such as monarch butterfly, Danaus plexippus, Heliconius melpomene, Dendroctonus ponderosae, Nasonia vitripennis), but the identity was much higher in Lepidoptera (Additional file 10).
