Examples and statistical results of EPIs are presented in section "Results".
Examples and statistical analyses of these data are given in the corresponding result sections.
This is usually done by first using a multiple sequence alignment (MSA) program (usually MAFFT [ 71] or MUSCLE [ 72] to align the tags, followed by the calculation of a distance matrix (using QuickDist [ 14] for example) and finally statistical analyses.
There were two design elements used for adaptation in this case example: population adaptation and statistical information adaptation.
This method is not perfect and poses various challenges; for example, both conceptual and statistical heterogeneity and incoherence between included studies should be carefully assessed.
This, along with comparative statistical tests, was used to test agreement between parents and patients and also as a test of reliability and an example of concurrent and statistical conclusion validity of the questionnaire.
Furthermore, the current screening tools for drug use, for example the Diagnostic and Statistical Manual of Mental Disorders IV for substance abuse, have not been validated for older populations [ 13], furthering problems of diagnosis.
Children and adolescents (aged from 6 to 18 years when they initially enrolled in the trials) with a primary diagnosis of current major depressive disorder according to standardised diagnostic interviews, for example, the Diagnostic and Statistical Manual of Mental Disorders (DSM) 30 32 or the International Classification of Diseases (ICD), 33 34 will be included.
In contrast, peer reviewers (ideally) focus on the validity of the actual scientific content and reporting, and flag for the editor failings in the methods (for example, in the experimental design and statistical analysis) or reasoning (for example, interpreting the results within the context of previous knowledge).
However, these studies varied significantly in terms of study design (including experimental materials and infection stages) and data analysis (for example, different statistical methods and various fold-change cutoffs).
