For example, alterations in the ECM simultaneously induce changes in viscoelasticity of the cartilage.
For example, alterations in the HPAA through fetal programming have been shown to increase the occurrence of respiratory, and skin diseases [ 16– 16].
Mechanisms underlying this resistance to 'classical' cytotoxic chemotherapeutics include many features, for example, alterations in the drug target, activation of prosurvival pathways and ineffective induction of cell death.
Specific awareness is advised for signs of cerebral edema (for example alterations in the level of consciousness, bradycardia, high blood pressure or inequality of pupillary size).
HATs also play roles in heart disease; for example, alterations in the levels of p300 can lead either to developmental cardiac defects or to hypertrophy and heart failure (Yao et al., 1998; Miyamoto et al., 2006; Wei et al., 2008).
For example, alterations in the length and positions of double bonds within the acyl chain of a lipid molecule can confer widely differing properties and suggest that specific proportions of distinct fatty acid classes may be necessary for optimum membrane function [ 48].
For example, alteration in TNFRSF10B transcript abundance may disrupt cell cycle control and induce the development of carcinogenesis.
A limited number of studies have investigated alterations in the expression patterns of regulatory genes in developing tissues in vivo in response to immobilisation, showing for example alteration in FGF2 [37], IHH and COLX [22].
For example, alterations in several RTKs have been identified, with the best described being dysregulation of RET present in 5-30% of sporadic PTC in adults [ 24, 25].
For example, alterations in activation in medial prefrontal regions including the ACC during processing of emotional stimuli predict relapse after 18 months in remitted MDD patients (11) and treatment response (12).
