"For example, abnormalities may be indicative of an intrauterine infection, maternal illness or poor fetal outcome," explains Clark.
For example, abnormalities in spatial memory could be tested.
For example, abnormalities in the ratio of the unedited/edited forms have been reported as a consequence of ischemia [38].
Over the last 20 years various facets of cellular and immunological dysfunctions in CVID have been described, for example, abnormalities in B cell populations, low frequencies of naive CD4 T cells, and an increase in cellular activation [10] [14].
For example, abnormalities in mitochondrial complex I have been observed in several infantile and childhood neurological disorders and in neurodegenerative diseases such as Parkinson's disease [1], [2] and motor neuron disease [3] while complex II dysfunction is seen in Huntington's disease [4], [5].
However, phenotypes not associated with (or secondary to) Escobar syndrome, for example abnormalities in temperature regulation, were also predicted.
In cancer, for example, abnormalities in fatty acid metabolism may contribute to the Warburg effect, cachexia, mitochondrial dysfunction, cancer aggressiveness and so on 13.
For example, abnormalities during B cell differentiation in secondary lymphoid tissues may permit the generation and survival of ISCs that secrete pathogenic autoantibodies.
Other proposed mechanisms are for example abnormalities in the growth hormone/insulin-like growth factor-1 axis [ 6– 8] and increased prevalence of anti-pituitary antibodies [ 9].
For example, abnormalities in myelination, axonal number, diameter and orientation can all lead to changes in FA and ADC (Beaulieu, 2002).
Future studies could include generation of protein profiles from such subregions, which might then provide insight into the specific molecular correlates of, for example, abnormalities in LTP.
