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For example, a trial of the monoclonal antibody trastuzumab would not be likely to show an overall survival benefit if subjects' expression of the target antigen is unknown at the time of randomization.
For example, a trial of the Canadian CT Head Rule showed that the use of this decision aid did not reduce the rates of CT imaging in Canadian emergency departments [ 22].
For example, a trial of an antifungal drug for the prevention of infection in neutropenic patients described the modified intention to treat as allowing "all patients that received at least one dose of study drug" to be included in analysis.
For the 10 journals that had published the highest number of papers (separately for randomised trials and systematic reviews) for each specialty and subspecialty in 2009 (the "top 10" journal list), we classified the journals as specialty, subspecialty, other specialty (for example, a trial of an intervention for patients with diabetes published in a cardiology journal), or general medical.
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For example, in a trial of 500 subjects, for a vaccine that has a 50% efficacy, misallocation of only 25 (5%) subjects has an estimated efficacy of 44% 95%% confidence interval (CI) of 41% 45%), and this is a relative error of ∼12% 955% CI of 10% 18%) from the true vaccine estimate (Figure 3a).
As another example, consider a trial of a community intervention to promote vaccination.
For example, consider a trial of educating primary care physicians for the treatment of acute shoulder pain.
For example, in a trial of breastfeeding support groups, leaders interpreted the word "support" in different ways.
For example, consider a trial of surgery vs. medical therapy, where patients are clustered within surgeons in one arm only.
For example, in a trial of pelvic floor muscle training for stress urinary incontinence, a 64% response rate was reported for the sham (placebo) intervention arm [ 46].
For example, in a trial of a topical treatment for HIV-related peripheral neuropathy, patients were required to record pain four times a day for four weeks at baseline and at follow-up, a total of 224 data points [ 7].
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