The Levitzki group also examined substituted aryl thioether analogs such as AG824 (Chart 1).
All conjugated ring cores examined, when substituted with an appropriate electron-withdrawing species, led to excellent RIC reduction.
These probes have been employed to examine phosphine substituted (Shell-type) and unsubstituted cobalt carbonyl oxo catalysts under catalytic and non-catalytic conditions in a variety of solvents.
The effect of carbon sources (with the same C molecular weight) on fungus growth and CHA production were examined by substituting glucose in the basal medium with various carbon sources.
The effect of R3 modifications on protein complex binding was examined by substituting R3 with alanine (R3A) or leucine (R3L) to eliminate the methylation target or to mimic increased hydrophobicity after methylation, respectively.
Associations that were significant at the p < 0.05 level in models with exposure represented as a continuous (log-transformed) variable we further examined by substituting tertiles of the biomarkers (micrograms per gram creatinine) to assess the linearity of the effects.
The effect of residue volume was examined by substituting Tyr with smaller (alanine) or larger (tryptophan) residues (residue volumes of alanine, phenylalanine, tyrosine and tryptophan are 67, 135, 141 and 186 Å, respectively [ 29]).
By dissecting DNA ligase functions and examining effects of substituting yeast DNA ligase with an exogenous viral ligase, we find moreover that unloading of PCNA by Elg1-RLC depends on completion of Okazaki fragment ligation.
What's the longest amount of injury time that's ever been played at the end of a period of extra time?" "At a recent and dull St Mirren match, where proceedings were brightened even by substitutions, I noted the fourth official examining the on-coming substitute's studs especially fastidiously, so much so that I thought he would not be allowed on," says Alistair Meldrum.
We measured the impact of school-located influenza vaccination (SLIV) on coverage, examined whether SLIV substitutes for practice-based influenza vaccination ("substitution"), and estimated whether a second year of experience with SLIV increases its impact.
