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As a follow up to our regression models, we examined pathways of mediation (Fig. 1).
Upregulated genes were found in 8 examined pathways.
All the genes exclusively overexpressed by FBR CD68+ cells in the 31 examined pathways are listed in table 1.
We therefore examined pathways that may be normalized by restoration of normoglycemia with kidney-pancreas (KP) transplantation.
A recent, comprehensive pathway resource from our lab, SignaLink, applies uniform curation rules to keep the levels of details to be identical in all examined pathways for C. elegans, D. melanogaster and humans [22].
In an attempt to uncover the mechanisms of action of resveratrol in retarding aging parameters and its ability to mimic CR, we examined pathways implicated in aging and CR.
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If the queried protein is not known to be a member of the examined pathway, then it is a signalog of that pathway.
In addition to documenting expression of Notch pathway components, several studies have examined pathway activation.
To date, only a single study has examined pathway activation status in UC.
In this report, we examined pathway information, functional domains and functions of piRNA-linked genes.
The resulting P value depicts the probability that the examined pathway is significantly enriched with gene targets of at least one selected miRNA.
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