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We have also provided evidence showing that these disease models could be used to examine the functional effects of chemical compounds as well as to re-purpose the old drugs already approved for different diseases in clinics.
To further examine the functional effects of integrin α3, the expression vector of integrin α3 was transiently transfected into the glioma cell lines utilised for siRNA experiments.
In this project we sought to examine the functional effects of over-expression of EWS/WT1-KTS and EWS/WT1 + KTS in primary murine embryonic fibroblasts.
To examine the functional effects of nephrin on cell activation by FFA, a nephrin deficient ciPod cell line (ND ciPod) was used.
We were interested to examine the functional effects of Lys103Met and Val160Gly substitutions in HPRT. Figure 1 shows the schematic structures of the wild type (left) and the mutant (middle) amino acids.
To examine the functional effects of the three novel mutations on H6PDH enzyme activity, both mutant and WT H6PDH sequences were used to transfect the HEK293 mammalian cell line.
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To examine the functional effect of AMFR and NOTCH1 in miR-139-5p-induced miR-139-5p-induced miR-139-5p-induced miR-139-5p-inducedd NOTCH1 expression with siRNA (Fig. S6) and revealed that AmetastasisOTCH1-depleted LoVo cells showed decreased inhibitionwhinh phenoCRCied the invasion-inhibiting effecells miR-139-5p.
To examine the functional effect of LG-histone adduction, we performed salt fractionation of A549 nuclei to determine histone solubility.
To examine the functional effect of placental arginase, PlaC and Jurkat cells were co-cultured to assay arginase-induced modulation of T cell responsiveness [ 21, 29].
To examine the functional effect of corneal arginase, corneas were homogenized and the tissue extracts were added to purified CD4+ T cells stimulated with anti-CD3 and anti-CD28 beads in the presence or absence of competitive arginase inhibitors, N-hydroxy-nor l-arginine (nor-NOHA), (S - 2-Boronoethyl)- l-cyS - 2-Boronoethyl.1 mM l-arginine.
We examined the functional effects of chemokines in expressed prostatic secretions of patients with chronic pelvic pain syndrome.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com