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In summary, we employed a tractographic approach to examine region specific FA, RD, and AD differences in the fornix and cingulum bundles.
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Our sequencing strategy would not have detected the presence of larger insertions/deletions and did not examine regions that likely control expression of the ATXN2 gene.
In order to minimise this, we chose to examine region-gene associations where the peak is within ±1Kb of the TSS.
To examine region-specific effects of the different graft-types within the host striatum, immunohistochemistry for c-Fos, the protein product of the early immediate response gene c-Fos, was performed on tissue from animals that received injection of amphetamine 2 h prior to perfusion.
Finding functionally similar sequences in evolutionarily related species requires algorithms to accurately align protein sequences and examine regions of conservation.
To classify a mutation as "mutually exclusive," we could only examine regions for which the copy number in the tumor is 1.
We used MEG to examine regions showing activity correlated with that of the hippocampal network [Smith et al., 2009], focussing on the theta band.
An incremental dynamic test was conducted up to the near-collapse state of the specimen, using input ground motions compatible with induced-seismicity scenarios for the examined region.
The worst LUS pattern detected in each zone was considered as characterizing the examined region.
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