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The established hot plate method is considered to be selective to examine compounds acting through opioid receptor [41].
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In order to examine compounding of ABS and nanoclay particles, an X-ray diffraction (XRD) test was conducted.
Among the tested compounds examined, compounds 3 7 showed significance difference from the standard drug ciprofloxacin.
All examined compounds are of typical layered structure at room temperature.
All the 67 examined compounds showed high MAO-B selectivity, some of them achieving potency in the low nanomolar range.
The N-para-fluorophenethyl derivative had the highest μ-opioid receptor affinity of the examined compounds (Ki = 0.35 μM).
Due to their long alkylester and alkylamine terminal groups the examined compounds were well soluble in organic solvents.
Among 24 compounds examined, compounds 21 and 23 showed significantly improved antiproliferative activity against MDA-MB231 and MDA-MB468 cancer cells.
Among the compounds examined, compounds 5b and 7a showed the highest activity, nearly equivalent to that of the standard drug diclofenac sodium.
Among the examined compounds, we found nordihydroguaiaretic acid (NDGA) has a unique and strong inhibitory effect on various TGF-β activities.
The results document that 5-sulfanylphthalimides are highly potent and selective MAO-B inhibitors with all of the examined compounds possessing IC50 values in the nanomolar range.
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