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After these initial examinations, specificity of all of the products was confirmed each time by melting curve analysis via LightCycler Software 3.39 (Roche).
When dynamic evaluation of tumour marker associations was considered with an accurate history and laboratory examinations, specificity, accuracy and PPV of CEA-TPA-CA15.3 tumour marker panel were higher than the corresponding of MCA-CA15.3 association.
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Results: At the 24-week examination, specificities for delivery at >32 weeks of gestation for digital examination (92.9%), fetal fibronectin level (93.9%), cervical length on sonographic scan (85.1%), and combined fetal fibronectin level and cervical length (81.3%) did not differ statistically.
When dynamic evaluation of tumour marker associations was considered with an accurate history and laboratory examinations, sensitivity, specificity, accuracy, NPV and PPV of CEA-TPA-CA15.3 tumour marker panel were higher than the corresponding of MCA-CA15.3 association.
In case of the examination of specificity of the 20 probes the outliers and obvious artefacts were also removed manually.
In a previous study even histological examination sensitivity, specificity, positive predictive value, negative predictive value and diagnostic accuracy were demonstrated to be reduced on acid reducing drugs [ 8].
This method was employed for examination of specificity of a rabbit antibody raised against a synthetic fragment 8-25 of rat α7 nAChR (Shelukhina et al., 2006).
Second, imaging examinations may lack specificity, resulting in the need for further examinations to differentiate the disease from tuberculosis, neoplastic disorders and yaws, for example.
After careful examination, the new specificity is one base pair shorter than the wild type enzyme.
Examination of tissue specificity of their mRNA expression by real-time PCR analysis revealed that both the XtCRYs showed extremely high mRNA expression levels in the ovary.
Examination of the specificity of PB gene expression profiles in response to different stimuli and the durability of these signatures over time will be critical to allow the translation of this strategy into clinical practice.
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