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These findings are consistent with other examinations of variation in care practices published in the literature.
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16 Bakeo's findings were broadly in line with our own for the risk factors examined, but in that work no examination of variation at the PCT level was undertaken, deprivation was not addressed directly (but only through the father's occupation), and maternity services funding was not addressed.
"The supposed scientific allure and perceived rigor of randomized control trials actually inhibits more useful comparative designs and thoughtful, detailed examination of variation".
Comparison of mammalian CARD8 orthologs and examination of variation among different human populations suggest that the increase in infectious-disease burden associated with larger animal groups (i.e., herds and colonies), and possibly human population expansion, may have naturally selected for loss of CARD8.
Examination of variation in cellular responsiveness to signaling modulation may be more informative.
Other approaches of diversity assessment involve the examination of variation of nucleotide GC content across taxonomic groups to detect unusual variation in mitochondrial GC content [28], [29], [35].
Although we did not identify variants leading to novel amino acid substitutions, nonsense or frameshift mutations, this study warrants further examination of variation in the ATXN2 gene in obesity and related phenotypes in a larger case-control study with emphasis on rs695872 and CAG repeat structure.
This will allow examination of variation in perceptions between participants.
For a broad scale examination of variation, we performed a principle components analysis of all samples.
The inclusion of a pain calendar will allow the examination of variation in joint pain over time.
Due to high sequence similarity, examination of variation in these TLR genes would require a separate study employing dedicated methods.
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