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Potential interplay between mTOR blockade using AZD8055 and ER signalling was further investigated by PCR examination of the ER regulated gene pS2 as well as several ER-regulated genes more closely related to breast cancer cell growth: amphiregulin (important in TamR cells; [ 36], bcl2 (expressed in MCF7-X only), c-myc and cyclinD1.
Examination of the genes regulated by BRDT yields many possible targets that could in part explain the morphologically abnormal sperm produced by the BRDT mutant testes.
To extend the in silico examination of the differentially regulated genes by IPA, we subjected DEGs that were common to TSA and CBHA to KEGG analysis.
Examination of the genes regulated in our cells by long-term treatment with oestrogen reveals an unexpected inverse relation (rs = - 0.23; P < 0.002) with expression association to ER status of the tumour.
Regulators become the prisoners of the regulated.
Examination of the most significantly regulated genes in pathways reveals that a number of genes from a few different gene families play a repeated role in multiple pathways that were regulated by chemical exposures.
Examination of significantly regulated gene transcriptional patterns provided an overview of sporulation associated rearrangements of metabolic and physiologic processes.
Examination of genes regulated by HP-14 in 2102EP and 2102EP-R revealed that HP-14 affects proliferation of both cell lines through activation of different pathways.
Further examination of these directly regulated target genes in the context of the correlated gene-list reveals important insights into how Oct4 regulates pivotal pathways involved in controlling pluripotency, self-renewal and early lineage commitment.
A closer examination of these differentially regulated genes after filtering at 10% FDR and FC greater than 5 as shown in Figure 7 revealed significant up regulation of red cell specific genes such as ankyrin, erythrocyte membrane protein band 3 and 4, hemoglobins and glycophorin A in sickle cell disease.
Examination of three differentially regulated TCS genes showed that Sll1124 is an orphan histidine kinase necessary for growth under blue light [ 57], Slr0222 is also an orphan functionally unknown histidine kinase, and sll1672 is clustered with a downstream response regulator Rre2 (sll1673).
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Justyna Jupowicz-Kozak
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