Exact(5)
We have carried out the first examination of pathways of cell differentiation in model genetic networks in which cell types are assumed to be attractors of the nonlinear dynamics, and differentiation corresponds to a transition of the cell to a new basin of attraction, which may be induced by a signal or noise perturbation.
However, detailed examination of pathways that regulate circadian E-box containing genes in AGRP neurons during energy deficit states is required.
In the subsection "Regulation of circadian genes by food-deprivation" we clarify: "However, detailed examination of pathways that regulate circadian E-box containing genes in AGRP neurons during energy deficit states is required".
An examination of pathways involved in xenobiotic and intermediary metabolism showed that while most pathways were suppressed during development, nine were up-regulated, the most prominent of those being purine and pyrimidine metabolism, likely activated to support DNA and RNA synthesis during active liver growth (Additional File 9, Figures S7 and S8).
A recent examination of pathways involved in the inhibitory effect of acupuncture showed that excitation of the ARC, similar to that induced by acupuncture, inhibits RVLM neuronal activity, whereas the inactivation of neurons in the caudal VLPAG abolishes ARC-mediated inhibition (VLPAG panel).
Similar(55)
Furthermore, functional enrichment of the two subnetworks and examination of pathway crosstalk highlighted shared "neurological disease" in the disease category and immune/kinase-regulatory/neurotransmitter related pathways in the canonical pathway category.
Thus this KEGG analysis is technically preliminary; therefore only a detailed examination of individual pathways will allow on to decide which pathways are actual active.
Examination of the pathways significantly perturbed in the three sets (as per Pathway-Express analysis) reveals that immune system signalling networks were the most abundant among the sets (Additional file 7).
Therefore, a more detailed examination of these pathways will be needed to ascertain the specific receptor-mediated transduction pathways functioning in PGCs.
After initially testing our hypothesis on the PI3 Kinase pathway, we decided to undertake a more extensive and rigorous examination of signalling pathways within the cell.
Continued examination of these pathways will undoubtedly provide vital insights into the mechanisms of GI development and disease and may afford new avenues for innovative tissue engineering and personalized medicine approaches to treating GI diseases.
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