Examination of nerves from 6-month-old C22 mice revealed Schwann cells with abnormal cytosolic PMP22 aggregates that were reactive for ubiquitin and were surrounded by autophagosomes and lysosomes (Fortun et al., 2006).
Modern ultrasonography for examination of nerves is attractive to a wide variety of medical practitioners due to its ease of use, portability, and efficiency, as well as the ability to image the entire length of a nerve in real-time (21).
All subjects underwent evaluation for classification of DSP according to clinical neurologic examination that included nerve conduction studies, the examination of small nerve fiber structure by IVCCM, and the examination of small nerve fiber function by CDT, LDIFLARE, and HRV.
Histological examination of the nerve showed more regenerating nerve fibres and less myelin debris in the group in which hNGFβ-modified MSC had been implanted than in the control group.
Bearing in mind the demonstrated anatomical risk to the obturator nerve, a thorough examination of obturator nerve function, including cutaneous sensation, is essential in patients presenting with groin pain following hip replacement.
The definition of definite neuropathy was based on the presence of at least three of the following: symptoms of neuropathy, signs based on an abnormal quantitative neurologic examination, abnormality of nerve conducting studies, quantitative sensory testing, quantitative sudomotor axon reflex testing, and skin biopsy with measurement of intraepidermal nerve fiber density (IENFD).
McNemar's test showed significant bias between MRI and physical examination findings of nerve involvement in most segments, except disturbed sensibility to touch where there was no bias in the three lower segments.
Figure 2 exemplifies a case in which MRI-visible nerve involvement was observed but there were almost no physical examination findings of nerve involvement, i.e. the specificity of MRI in determining nerve involvement was questionable.
It was less an examination of technique, more a test of nerve.
The gold-standard method for evaluating such morphological change in small nerve fibers can be accomplished by the examination of intraepidermal nerve fibers in skin biopsy samples (9).
