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It is not clear whether this is technical or biological, although the difference in magnitude seems too great to be biological, and examination of methodological points wherein differences might occur on the order of two-fold doesn't account for the orders of magnitude difference in results.
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In addition, in studies involving the application of biomarkers to cancer epidemiology it is imperative that a typical biomarker concentration is not associated with breast cancer risk before further examination of the methodological limitations of epidemiological studies investigating this relationship.
Examination of practical, theoretical and methodological values of findings includes considering research needed and the utility of safety measure information in business decision making.
In this paper, we provide a methodological examination of the potential sources of bias in observational studies of influenza vaccine effectiveness in seniors and propose design and analysis strategies to reduce bias in future studies.
Carter [ 1] presented a methodological examination of this issue and developed a statistical model to estimate the accrual period of a clinical trial.
Examination of key clinical and methodological uncertainties in the exploratory trial phase could help researchers to set up definite randomised controlled trials and guide long-term implementation.
To avoid extreme variations of methodological quality, only randomised controlled trials, controlled trials and clinical trials were taken into account for further examination.
Comparison of the present data with international caries data for preschool children must take account of methodological differences such as use of national survey data versus sub-samples, differing age ranges, ECC definitions and examination criteria.
However, a closer examination of some of this work reveals some methodological and interpretive concerns.
Recent methodological advances allow better examination of speciation and extinction processes and patterns.
Methodological issues included the examination of the characteristics of the sample and the technical quality of data collection methods.
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