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Longitudinal follow-up and examination of mechanisms of action as they relate to psychosocial and glycemic outcomes will be explored in the future.
16 The development of biomarkers for sarcopenia is of particular value in the examination of mechanisms, diagnosis, and responses to treatment.
Accordingly, the PC12 model is suitable for examination of mechanisms underlying adverse effects on multiple developmental stages ranging from cell replication through end-stage neural differentiation.
Therefore, this review catalogs recent advances in natural product-based drug discovery via the examination of mechanisms of action and available clinical data to highlight the utility of these novel compounds in the burgeoning age of precision medicine.
Reviewer 3: This manuscript by Ratté et al describes theoretical and experimental examination of mechanisms of hyperexcitability of sensory neurons from the rat in the context of nerve injury pain.
Finally, an examination of mechanisms of spindle orientation in oRGs would be very exciting, as these seem to undergo asymmetric divisions in the complete absence of an apical domain to help govern the orientation.
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The model has been validated in studies of basic functions of the BBB at the cellular and molecular level, screening of drug entry into brain for pharmaceutical purposes, and examination of mechanism(s) for CNS entry of 'biologicals' (large organic molecules) (Patabendige et al., this issue; Skinner et al., 2009).
In conclusion, their reproducible production and standardized quality renders HaCaT organotypic cocultures an excellent tool for large scale examinations of mechanisms regulating skin reepithelialization and homoeostasis in a tissue-type context.
Therefore, an examination of disease mechanisms involved in pyometra may provide important insights to the mechanisms operating during human bacterial infection and sepsis [15], [16].
The examination of such mechanisms is necessary for a fuller understanding of policy implementation and grassroots governance.
Thus the close examination of focal mechanisms helps to investigate the existence and effect of crustal fluids to the seismogenic processes.
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