Once a tree with all PARP domains had been generated, it was used to identify the six clades referred to in the text in combination with examination of domains outside of the PARP catalytic domain.
It is clear that the use of an exploratory mixed methods approach is valuable in the examination of domains and factors affecting technology adoption and implementation in small organizations.
We defined six clades of PARPs based on our maximum-likelihood tree, an examination of domains found outside of the PARP catalytic domain used to generate that tree and the evolutionary relationships of organisms within clades (Clades 1-6; Figure 1).
This chapter describes methods and strategies for cloning, expression, and purification of GCSs for spectroscopic analysis and determination of the minimum heme-binding domain, together with bioinformatic approaches for database searching and examination of domain architectures.
In other words, its formation was not defined by a need to deal with scale; rather, it was defined by virtue of the techniques that computer science brought to the formulation and solving of challenging problems, to the representation and examination of domain knowledge, and ultimately to the generation and testing of scientific hypotheses.
Further, the extent of repeat was verified through structural alignment methods such as DALI [18], LSQMAN [19] and also through the examination of domain topologies with HERA [20].
Focused examination of domain-specific gene ontology remodeling revealed a general enrichment of Cardiovascular Development in the truncation variants, with unique prioritization of "Cardiovascular Disease" exclusive to the cohort of down regulated genes of the PC truncation variant.
In the current study, the researchers parsed estrogen receptor activity based on a detailed examination of functional domains characteristic of both receptor subtypes: the N-terminal domain, which includes activation function 1 (AF-1), and the C-terminal ligand-binding domain, which contains AF-2.
It is possible that examination of other domains would expose other trajectories and relationships.
The assessment of the neurotoxicity studies drew conclusions through an examination of affected domains (e.g., cognition, vision, motor activity).
In further examination of barrier domains to healthcare utilization, compared to non-fatigued persons adjusted ORs for CFS having "accessibility", "KAB" and "Healthcare System" barrier domains decreased by 40%, 30%, and 19%, respectively.
