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The available evidence suggests that radiography is better than clinical examination for defining hand OA in epidemiological studies, and that it is possible to identify persons with clinically significant OA by combining a radiographic criterion with self-reported symptoms [ 32].
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We excluded men who were receiving testosterone or androgen-deprivation therapy for prostate cancer or those who had missing testosterone or other data necessary for defining metabolic syndrome at either examination 7 or examination 8.
The date for head CT examination was defined as the index date and the start of follow-up set at 2 years after the index date (lag period of 2 years).
The relevant areas for the combined SPECT/CT examination were defined based on a prior whole-body planar scintigraphy.
Diagnostic efficacy (primary endpoint) of the CT examination was defined as the level of available information for diagnosis provided by the MDCT examination.
Gobena et al. have used detailed post mortem examination to define the BTB disease status of Ethiopian cattle for the evaluation of SICCT in this setting [26].
For the purposes of this study, a duplicate examination was defined as the occurrence of the same imaging examination (i.e., identical OHIP fee code) within a specified time frame after the index test.
The interval since the preceding negative examination is defined as the time between the last negative primary examination and the screening examination for screen-detected carcinomas and the time between the last negative primary examination and the histological confirmation of invasive cancer for cancers detected because of symptoms.
The primary shoulder for examination purposes was defined by coin toss.
An acceptable examination was defined as > 80% correct scores.
For each examination method, we defined the result as "possible delineation", "successful delineation" or "unsuccessful delineation" as follows (Figs. 2 and 3).
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