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A history, blood pressure measurement, and urine protein/creatinine ratio were performed before each bevacizumab dose, with detailed history and physical examination every cycle (Azad et al, 2008b).
Toxicity, graded according to National Cancer Institute Common Toxicity Criteria (NCI-CTC) version 1, was assessed by clinical examination every cycle, weekly for haematology and every two cycles for biochemistry.
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In our study, patients were routinely monitored for cardiac events by clinical examination and every cycle evaluation of left ventricular ejection fraction.
Clinical examination was performed before every cycle and 21 days from the end of therapy.
Subsequent cardiac evaluation consisted of physical examination, and ECG recording every cycle, and echocardiography monitoring for L-VEF determination every two cycles during treatment, after the last course of chemotherapy, and at 3-month intervals during the follow-up period.
Patients underwent physical examination on day 1 of every cycle.
Participants underwent a physical examination, maximal cycle ergometer testing, electrocardiography, echocardiography, and laboratory tests at baseline (day −270) and received a written training program at the start of the training period (day −180).
A total of 27 340 residents aged ≥3 years were invited by telephone call, of which 15, 010 residents participated in first examination cycle and another 3,551 residents were first examined at the second examination cycle.
Participants attended the offspring seventh examination cycle (1998 2001) or the third-generation first examination cycle (2002 2005) and had complete risk factor information (including fasting glucose, BMI, blood pressure, lipids, smoking, and diabetes status) (see Supplementary Table 1 for clinical characteristics of each cohort).
This method allows for examination of cell cycle events in cells progressing normally into a new cell cycle.
All attendees at the 22nd examination cycle of the original cohort (referred to as the "index" examination; n = 1,173) were eligible for the present investigation; we excluded individuals with nonavailable leptin levels (n = 355).
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