Although no statistically significant differences in core temperature were observed between groups, there were trends towards attenuated hypothermia in HC-067047-treated mice, and exaggerated hypothermia in TRPV4 KO mice, relative to vehicle-treated counterparts.
This movement is largely exaggerated in pcd mice.
On the other hand, other functions, especially regarding TAp63, may not be impaired or even exaggerated in Brdm2/Brdm2 mice, and studies of these functions indeed require careful re-interpretation.
When challenged with either intratracheal zymosan or LPS, NADPH oxidase-deficient p47phox−/− mice and gp91phox-deficient mice developed exaggerated and progressive lung inflammation, augmented NF-κB activation, and elevated downstream pro-inflammatory cytokines (TNF-α, IL-17, and G-CSF) compared to wildtype mice.
On the other hand, Y1/Y2 receptor double KO mice exhibited exaggerated fear acquisition compared with Y1 receptor KO mice, strongly suggesting a dominant role of Y2 receptor deletion on fear learning while the contribution of Y1 receptors may be only of only minor significance.
However, in response to myocardial infarction (MI), these mice suffer exaggerated cardiac damage and increased mortality compared with wildtype (WT) mice.
Optogentics US of CaMKIIa ILSCm neurons in a mouse elicits exaggerated innate freezing followed by sustained anxiety-like responses and this response is quickly adapted by repeated application of stimulation.
High or low SKCa expression in arteries of SK3 transgenic mouse, respectively, exaggerated or abolished the tonic endothelial dilating influence [ 84].
In contrast to sham-treated mice (saline injection in the calcaneous bone), tumour-bearing mice demonstrated exaggerated sensitivity and aversive withdrawal responses to very low, normally innocuous intensities of mechanical force (e.g. 0.07 g).
6) The study reports two sets of findings: first, that EPI mice are protected from DMBA/TPA induced skin papillomas; second, that EPI mice have exaggerated inflammatory response to TPA.
